Chewable tablets from white to brownish color with brownish spots, round shape.
Composition
One tablet contains the active ingredient
- lotilaner - 48 mg for cats weighing >2 - 8 kg.
Excipients: yeast powder (flavor), silicified microcrystalline cellulose, powdered cellulose, lactose monohydrate, povidone K30, crospovidone, sodium lauryl sulfate, vanillin (flavor), colloidal anhydrous silicon dioxide, magnesium stearate.
Pharmacological properties
ATC-vet classification code: QP53, ectoparasiticides, isoxazolines (QP53BE04 ectoparasiticides for systemic use).
Lotilaner — it is a pure enantiomer, belongs to the group of isoxazolines, has insecticidal (Ctenocephalides felis and Ctenocephalides canis) and acaricidal (Ixodes ricinus) effects.
Lotilaner is a powerful inhibitor of GABA (γ-aminobutyric acid)-gated chloride channels, which leads to the rapid death of ticks and fleas. In in vitro studies, parasite resistance to organochlorines (cyclodienes, e.g., dieldrin), phenylpyrazoles (e.g., fipronil), neonicotinoids (e.g., imidacloprid), formamidines (e.g., amitraz), and pyrethroids (e.g., cypermethrin) did not affect the activity of lotilaner against some species of arthropods.
On fleas, the drug begins to act within 12 hours after their attachment to the host and continues to act for one month after application. Fleas that were on the animal before using the drug die within 8 hours.
The drug begins to act on ticks within 24 hours after their attachment to the host and continues to work for one month after using the drug. Ticks that were on the animal before using the drug die within 18 hours.
The drug causes the death of both existing fleas and those that have just appeared in cats, before the female flea has time to lay eggs. Thus, the drug disrupts the life cycle of fleas and prevents the risk of contamination of animal habitats.
After oral administration, lotilaner is easily absorbed in the digestive tract, the maximum concentration in the blood is reached after 4 hours. When used with food, the bioavailability of lotilaner increases approximately 10 times. The final half-life is about 4 weeks (harmonic average), which ensures the appropriate concentration in the blood and the effectiveness of the drug during the entire period between doses.
Lotilaner is excreted from the body mainly with bile, and renal excretion is a secondary route of elimination (less than 10% of the dose). Lotilaner is metabolized to a minor extent to more hydrophilic compounds observed in feces and urine.
Application
Treatment of cats with fleas and ticks.
The drug has immediate and persistent activity against fleas (Ctenocephalides felis and S. canis) and ticks (Ixodes ricinus) for one month.
Fleas and ticks must attach to the cat and start feeding in order for lotilaner (the active substance of the drug) to start working on them.
The drug is also used in complex therapy of allergic dermatitis caused by fleas.
Dosage
Tablets are given once orally individually during feeding or within 30 minutes after feeding in a dose of 6-24 mg of lotilaner per 1 kg of the animal's body weight.
Credelio dose for cats, chewable tablets 48 mg — one tablet of the drug for cats with a body weight of >2 - 8 kg.
For cats weighing more than 8 kg, an appropriate combination of available dosages should be used to achieve the recommended dose of 6-24 mg lotilaner per 1 kg of animal body weight.
For optimal control of ticks and fleas, the drug should be applied once a month throughout the entire season of flea and tick activity in accordance with the epizootic situation in your area.
Contraindications
Do not use in cats with known hypersensitivity to active substances or auxiliary substances.
Side effect
Based on post-marketing safety experience, very rare cases of vomiting have been reported, which usually resolve without treatment.
Disclaimer
Safety and efficacy data were studied in cats 8 weeks of age and older weighing 0.5 kg or more. Therefore, the use of this drug in kittens under the age of 8 weeks or with a body weight of less than 0.5 kg should be based on a benefit/risk assessment determined by a veterinarian.
Due to insufficient data to confirm effectiveness against ticks in young cats, the drug is not recommended for use against ticks in kittens under the age of 5 months.
Parasites must start feeding after attaching to the animal so that lotilaner (the active substance of the drug) starts acting on them; therefore, the risk of transmission of diseases cannot be completely excludedwhich are transmitted through parasites.
Acceptable levels of efficacy may not be achieved if the veterinary medicinal product is not administered during a meal or within 30 minutes after feeding.
Use during pregnancy, lactation
Laboratory studies in rats revealed no evidence of teratogenicity or any adverse effects on male or female reproductive capacity. The safety of using the drug for cats during pregnancy and lactation has not been established. During pregnancy and lactation, use only under the conditions of assessing the benefit/risk ratio determined by a veterinarian.
Special precautions for persons and service personnel
Hands should be washed after working with the drug.
In case of accidental ingestion of the drug, it is necessary to immediately consult a doctor and show the package or leaflet.
Release form
Tablets 48 mg for cats weighing >2 - 8 kg.
The drug is produced in aluminum foil blisters of 1, 3 or 6 chewable tablets, packed in cardboard boxes.
Storage
Store the drug in the manufacturer's closed package at a temperature not higher than 30 °C.
Keep out of the reach of children.
Expiry date
3 years if stored in original packaging.
For use in veterinary medicine!
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