COMPOSITION

100 ml of the product contains the following active ingredients: fluorophenicol - 2.5 g, prednisolone acetate - 0.1 g.

Excipients: methylpyrrolidone, polyvinylpyrrolidone, ethyl alcohol, isopropyl alcohol, propylene glycol, glycerin, dimethyl sulfoxide.

PHARMACEUTICAL FORM

Transparent liquid, colourless or light yellow.

PHARMACOLOGICAL PROPERTIES

ATC vet classification code QD06A - antibiotics for topical use.

Fluorophenicol is a thiamfenicol derivative in which the hydroxyl group is replaced by a fluorine atom, which determines its antibacterial activity against acetyltransferase-synthesising bacteria.

Fluorfenicol has bacteriostatic effect on gram-positive (Streptococcus spp., Staphylococcus spp.) and gram-negative (Fusobacterium necrophorum, Bacteroides melaninogenicus, Pasteurella spp, Salmonella spp., Proteus spp., Pseudomonas spp. Chlamydia spp.

Fluorfenicol inhibits protein synthesis in bacterial cells. In the protoplasm, it binds to 70S ribosomal subunits, inhibits peptidyl transferase enzyme activity, thus inhibiting protein synthesis in the ribosomes of the respective bacteria.

When administered topically, fluorfenicol acts locally and hardly penetrates the circulatory system. In animals, it is metabolised to form the metabolite fluorfenicolamine. Fluorfenicol and its metabolites are excreted primarily in urine, and to a lesser extent in faeces.

Prednisolone is a synthetic glucocorticoid. It has anti-inflammatory, anti-allergic and anti-exudative effects. Anti-inflammatory effect is due to inhibition of arachidonic acid metabolism and release of inflammatory mediators.

When applied topically, prednisolone is absorbed and enters the bloodstream. In plasma, 90% of prednisolone is bound (with transcortin and albumin). It is biotransformed by oxidation mainly in the liver; oxidised forms are glucuronidated or sulfated. It is excreted in urine and faeces in the form of metabolites, partially unchanged.

APPLICATION

Treatment of dogs, cats and rabbits of decorative breeds suffering from dermatitis, panarrhizia, pyoderma, eczema, as well as wounds (including after castration), combing, bites, bruises, ulcers caused by microorganisms sensitive to fluorfenicol.

DOSAGE

Before applying the drug, the affected area should be thoroughly cleaned of exudate and necrotic tissue.

Hold the pre-shaken vial at a distance of 5-10 cm from the surface of the damaged skin area, press the sprayer 1-2 times and treat the surface with a size of approximately 5x5 cm.

The drug should be applied every 12 hours until complete healing.

The duration of treatment depends on the extent of the lesion and the speed of healing.

CONTRAINDICATIONS

Do not administer to animals with hypersensitivity to the drug components.

Do not administer in combination with thiamfenicol or chloramphenicol.

SIDE EFFECTS

Allergic reactions are possible in case of individual hypersensitivity to the drug components.

PRECAUTIONS

Avoid contact with eyes of animals and humans. Do not allow the animal to lick the drug for 5 minutes. Shake the vial before use.

Treatment of animals with the drug should be carried out away from open flames and heating devices.

PACKAGE FORM

Polymeric vials with a spray bottle (spray) of 9, 100 ml.

SHELF LIFE

2 years.

Shelf life after the first use: until the expiry date.

STORAGE

Dark place, out of the reach of children at temperatures from 5°C to 25°C.

For use in veterinary medicine!