Liquid cosmetic and hygienic product for animal ear care

Composition

1 ml of the drug contains:

active substance: polymyxin B – 10,000 IU, neomycin sulfate – 5,000 IU, lidocaine hydrochloride – 40.0 mg, sulfirem – 50.0 mg, dexamethasone sodium phosphate – 1 mg, an extract of marigolds - 10.0 mg, chamomile extract – 10.0 mg, ochanka extract – 10.0 mg.

excipients: polysorbate 20 (E432), sorbitan laurate (E493), dimethylsulfoxide-propylene glycol up to 1 ml.

Pharmacological properties

Polymyxin B – a polypeptide antibiotic that belongs to the group of polymyxins. It affects the cytoplasmic membrane of the microorganism, interacting with phospholipids. This leads to a violation of membrane permeability. Polymyxin B – active against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus spp. 

Neomycin – aminoglycoside antibiotic with a broad spectrum of bactericidal action against gram-negative and gram-positive microorganisms: Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, Proteus spp., Salmonella spp., Streptococcus spp., Staphylococcus aureus.

The mechanism of action consists in inhibition of protein synthesis in the microbial cell.

Sulfirem has an antiparasitic effect against the ear mite Otodectis cynotis and a fungicidal effect against the yeast Malassezia pachydermatis (Pityrosporum canis).

Lidocaine inhibits the sensitive nerve endings of the skin and mucous membranes, that is, it causes a reversible inhibition of the conductivity of tissue elements of nerve cells (neuron, axon, synapses). Violates the function of potential-dependent sodium channels, reduces sodium entering the cell, prevents the formation of an action potential and the conduction of an impulse.

The flower tip contains carotenoids (carotene, lycopene, violaxanthin, citraxanthin, rubixanthin, flavochrome), flavonoids (narcisin, rhamnetin, isorhamnetin-3-triglucoside, isoquercitrin), essential oil, saponins, calendula bitter substance, resinous and tannic substances, mucilage, inulin, organic acids (malic, salicylic, pentadecylic), phytosterol, enzymes, vitamin C, alkaloids. This complex of biologically active substances has an anti-inflammatory, wound-healing, bactericidal effect, accelerates tissue regeneration processes. 

Daisy flowers – biologically active substances have a pain-relieving, anti-inflammatory, antiseptic effect, reduce allergic reactions, enhance regeneration processes

Ochanka flowers and leaves – contain essential and fatty oils, flavonoids, tannins, coumarins, glycosides, anthocyanins, as well as vitamins. 

Ochanka flowers and leaves have a positive effect on visual acuity, reduce inflammatory processes, even have a therapeutic and preventive effect on degenerative-dystrophic processes in the eye membrane, as well as reduce puffiness of the eyes and slow down age-related exchange violations.

Application

Dogs and cats: acute and chronic otitis media caused by bacteria, fungi or parasites. Allergic, eczematous or ulcerative changes in the external ear canal.

Dosage

The bottle must be shaken before use.

The drug is prescribed 1-2 times a day depending on the animal's body weight:

• dogs weighing up to 5 kg and cats – 3 drops;
• dogs weighing from 5 to 10 kg – 5 drops;
• dogs weighing more than 10 kg – 10 drops.

Term of treatment for acute otitis – 7 days.

Term of treatment for chronic otitis – 12 days

Contraindications

• Increased individual sensitivity to the components of the drug. 
• Damage of the tympanic membrane. 

Disclaimer

Before using the drug, the auditory canals of the eyesprotect from earwax, scabs and plugs.

Packaging

Polymer or glass vials with a dropper of 5 ml or 10 ml, or 15 ml, or 30 ml in a box.

Storage

In the original packaging, in a place inaccessible to children and animals at a temperature from 2 °C to 25 °C.

Expiry date – 2 years.

The shelf life of the solution after opening the bottle is 28 days.